Platelet Regulation of Angiogenesis, Tumor Growth and Metastasis by Jessica Cedervall

Cover of: Platelet Regulation of Angiogenesis, Tumor Growth and Metastasis | Jessica Cedervall

Published by INTECH Open Access Publisher .

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ContributionsAnna-Karin Olsson, author
The Physical Object
Pagination1 online resource
ID Numbers
Open LibraryOL27093026M
ISBN 109535100092
ISBN 109789535100096
OCLC/WorldCa884205366

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Tumor Angiogenesis from immune recognition and shear stress in the circulation. Platelets may also enable easier tumor cell adherence and subsequent ex travasation through the vessel wall.

The current chapter will review the role of platelets in regulation of angiogenesis, tumor growth and :// Platelet Regulation of Angiogenesi s, Tumor Growth and Metastasis granules in platelets, might also affect the metastatic process by enhancing the vascular Jessica Cedervall and Anna-Karin Olsson (February 17th ).

Platelet Regulation of Angiogenesis, Tumor Growth and Metastasis, Tumor Angiogenesis, Sophia Ran, R Regulation of tumor angiogenesis and metastasis by FGF and PDGF signaling pathways.

Our recent studies show that quiescent vascular endothelial cells usually remaining silence to platelet-derived growth factor (PDGF)-BB stimulation acquire their hyperresponsiveness after stimulation with fibroblast growth factor (FGF)-2, which Thrombin activates PAR1 and PAR2 receptors expressed by host and tumor cells, and generally supports tumor growth, angiogenesis and metasta Mechanisms by which platelets assist hematogenous metastasis depend on the ability of platelets to act in concert with coagulation factors in protecting tumor cells within the blood :// Tumor growth and metastasis depend on angiogenesis: several clinical studies have shown a positive correlation between the number of vessels in the tumor, metastasis formation and disease prognosis.

Therefore, inhibiting angiogenesis is a major area of therapeutic development for treatment of ://   The interaction of tumor cells with platelets is a prerequisite for successful hematogenous metastatic dissemination.

Upon tumor cell arrival in the blood, tumor cells immediately activate platelets to form a permissive microenvironment. Platelets protect tumor cells from shear forces and assault of NK cells, recruit myeloid cells by secretion of chemokines, and mediate an arrest of the tumor Platelets -winner of a Highly Commended BMA Medical Book Award for Internal Medicine - is the definitive current source of state-of-the-art knowledge about platelets and covers the entire field of platelet biology, pathophysiology, and clinical ly there has been a rapid expansion of knowledge in both basic biology and the clinical approach to platelet-related diseases   The formation of new blood vessels is essential for normal development, tissue repair and tumor growth.

Here we show that inhibition of the kinase p38α enhances angiogenesis   The role of angiogenesis in tumor growth has been studied continuously for over 45 years.

It is now appreciated that angiogenesis is also essential for the dissemination and establishment of tumor metastases. In this review, we focus on the role of angiogenesis as a necessity for the escape of tumor   Palumbo, J.

et al. Spontaneous hematogenous and lymphatic metastasis, but not primary tumor growth or angiogenesis, is diminished in fibrinogen-deficient Angiogenesis is, in fact, a hallmark of cancer, being necessary for both the growth (progression) and spread (metastasis) of cancer.

Before a tumor can grow to larger than a few millimeters in size, new blood vessels are needed to ensure an adequate supply of oxygen and nutrients to the ://   Abstract Background. Experimental evidence suggests that the growth of a tumor beyond a certain size requires angiogenesis, which may also permit metastasis.

To investigate how tumor angiogenesis Increased angiogenesis provides better access of these cells to the blood stream favoring metastasis dissemination that gains through the assistance of platelets. 3 The hypothesis that platelets may control tumor angiogenesis was developed 2 decades ago based on the rationale that they are a rich source of angiogenesis modulators and they //1/24//Metastasis-new-functional-implications-of.

Tumor angiogenesis is the main process responsible for the formation of new blood vessels that promote tumor growth and metastasis. This process is driven by potent pro-angiogenic factors that are predominant in the tumor environment and are produced by both malignant cells and the host cells recruited to the tumor site.

Tumor environment is characterized by the imbalance between pro The results suggest that platelet agonists as well as tumor cells can manipulate new blood vessel growth by stimulating the differential release of angiogenesis regulatory proteins from platelets.

In addition, our data suggests that the antiplatelet drug, aspirin may block the differential release of angiogenic regulators from platelets thereby //Release-of-angiogenesis-regulatory-proteins-from.

In a fast-growing malignant tissue, tumor blood vessels are exposed to multiple growth factors and cytokines. Although the role of individual factors and their signaling pathways in regulation of tumor neovascularization is relatively well-studied, little is known about complex interactions between these factors and their cooperative effects in promoting tumor angiogenesis and ://   Platelet regulation of tumor angiogenesis and tumor growth.

Angiogenesis in adults play an important role in wound healing, female reproductive cycle but also in pathologic processes, such as diabetic retinopathy, cancer and other inflammatory disorders [].The process of angiogenesis is regulated by balance of positive and negative :// Angiogenesis is considered one of the hallmarks in tumor growth and metastasis [7], in which the heterogeneity of vascular endothelial cells (ECs) and de novo arteriogenesis may play important   Coagulation promotes tumor growth and angiogenesis.

In certain models, TF signaling was demonstrated to be crucial for breast cancer growth. These findings are perhaps explained by the fact that TF can enhance angiogenesis indirectly through thrombin generation, fibrin deposition, and platelet activation [68, 72].

The functions of these growth factors in cancer invasion, angiogenesis, and metastasis have been well characterized. It is important to determine whether the Hsp47/collagen axis induces these pathways and the release of platelet-derived factors, and subsequently promotes formation of the premetastatic :// Tumor growth and metastasis depend on angiogenesis: several clinical studies have shown a positive correlation between the number of vessels in the tumor, metastasis formation and disease prognosis.

Therefore, inhibiting angiogenesis is a major area of therapeutic development for treatment of ://(97) Abstract. The growth and metastasis of solid tumors are dependent on the ability of tumor cells to induce angiogenesis [1].

Angiogenesis, the formation of new blood vessels from pre-existing ones, involves endothelial cell proliferation, motility, and tubular :// Spontaneous hematogenous and lymphatic metastasis, but not primary tumor growth or angiogenesis, is diminished in fibrinogen-deficient mice.

Cancer Res. ; – Medline Google Scholar; 7 Palumbo JS, Kombrinck KW, Drew AF, Grimes TS, Kiser JH, Degen JL, Bugge TH. Fibrinogen is an important determinant of the metastatic potential   Based on its effects on tumor and endothelial cell behavior, this member of the thrombospondin gene family has attracted interest as a potential regulator of tumor growth and metastasis.

Initial studies have confirmed that increased TSP1 expression suppresses growth or metastasis of some tumors in vivo and inhibits :// Tumor angiogenesis is the result of an imbalance between positive and negative angiogenic factors released by tumor and host cells into the microenvironment of the neoplastic tissue.

The stroma constitutes a large part of most solid tumors, and cancer-stromal cell interactions contribute functionally to tumor growth and metastasis. Activated fibroblasts and macrophages in tumor stroma play This book is the first to summarize current knowledge about the importance of protein precursors maturation by the convertases in tumor progression, angiogenesis and metastasis.

In each chapter, the importance of the convertases in the activation of various cancer-related molecules including growth factors, adhesion molecules and proteases is  › Biomedical Sciences › Cancer Research. angiogenesis physiology, and tumor vascularization, and highlights therapeutic targets aimed at suppressing angiogenesis.

Researchers are now favoring a combination of strategies, which target different stages of angiogenesis in order to prevent tumor growth and expansion. Angiogenesis is the generation of new blood vessels from The critical role of platelets in tumor progression has been investigated for more than 50 years.

To date, many different mechanisms of the interactions between cancer cells and platelets have been revealed, most of which involve the recruitment of activated platelets for facilitating tumor growth, angiogenesis, and ://   well as in PAIdeficient mice Similarly, tumor growth of subcutaneously injected murine prostate cancer cells was significantly retarded in uPA- or uPAR-deficient mice compared with wild-type mice Importantly, the inhibition of the uPAR system prevented or reduced the tumor growth and metastasis in animal :// It has long been recognized that platelets play an important role in the regulation of tumor growth and metastasis into the vascular space.

However, the underlying mechanisms by which the platelet-tumor interaction is mediated and how this aids in tumor extravasation and re-seeding has remained elusive.

Platelets release a number of signaling proteins, molecules, and ://   Platelets - winner of a Highly Commended BMA Medical Book Award for Internal Medicine - is the definitive current source of state-of-the-art knowledge about platelets and covers the entire field of platelet biology, pathophysiology, and clinical medicine.

Recently there has been a rapid expansion of knowledge in both basic biology and the clinical approach to platelet-related diseases   Saharinen P, Eklund L, Pulkki K, et al. VEGF and angiopoietin signaling in tumor angiogenesis and metastasis. Trends Mol Med ;17(7) Costa C, Soares R, Reis-Filho JS, et al.

Cyclo-oxygenase 2 expression is associated with angiogenesis and lymph node metastasis Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors, which function as transcription factors. Among them, PPARβ/δ is highly expressed in endothelial cells. Pharmacological activation with PPARβ/δ agonists had been shown to increase their angiogenic properties.

PPARβ/δ has been suggested to be involved in the regulation of the angiogenic switch in tumor ://   Angiogenesis is essential for tumor growth and metastasis. Understanding the regulation of tumor angiogenesis has become increasingly important.

MicroRNAs (miRNAs) are small noncoding RNAs that function in diverse biological processes via post-transcriptional regulation. Extensive studies have revealed two important regulatory roles of miRNAs in tumor angiogenesis: miRNAs in tumor Spontaneous hematogenous and lymphatic metastasis, but not primary tumor growth or angiogenesis, is diminished in fibrinogen-deficient mice.

Cancer Res. ; – Medline Google Scholar; 43 Biggerstaff JP, Seth N, Amirkhosravi A, Amaya M, Fogarty S, Meyer TV, Siddiqui F, Francis JL.

Soluble fibrin augments platelet/tumor cell   Since angiogenesis is an essential component in tumor growth and metastasis, controlling tumor-angiogenesis is an effective strategy to inhibit tumor development.

Thus far, VEGF/VEGFR targeted agents such as bevacizumab, sorafenib, and sunitinib have been shown effectively in prolong survival for some cancer ?genre. Aspirin impeded tumor metastasis, angiogenesis, and growth in heparanase-dependent manner. Conclusions: In summary, this study has illustrated heparanase as a target of aspirin for the first time.

It provides insights for a better understanding of the mechanisms of aspirin in anticancer effects, and offers a direction for the development of   The Tumor Progression and Metastasis [TPM] Study Section reviews grant applications on basic mechanisms of cancer progression, metastasis, and angiogenesis.

Special emphasis is placed on hypoxia, adhesion, migration/invasion, circulatory dissemination, dormancy and growth at distant :// Extract treatment in mouse model xenografted with human melanoma cells resulted in a dramatic antitumor effect with down­regulation of VEGF expression.

The results suggest that suppression of tumor growth by Cordyceps militaris extract is, at least, mediated by its anti-angiogenicity and apoptosis induction ://. Keywords:PAF, cancer, angiogenesis, metastasis, PAF-receptor, PAF-inhibitors, antioxidants.

Abstract: Cancer is one of the leading causes of death in Europe and United States. New blood vessel formation penetrating into solid tumors seems to be required for their growth and   Tissue factor, the primary initiator of the coagulation cascade, maintains vascular integrity in response to injury.

It is now recognised that, in addition to the role as a procoagulant activator, tissue factor participates in many tumour-related processes that contribute to malignant disease progression.

The present review details the recent evidence supporting a role for tissue factor in   The role of interleukin-8 and its receptors in gliomagenesis and tumoral angiogenesis Daniel J.

Brat 2 Send correspondence to Erwin G. Van Meir, Laboratory of Molecular Neuro-Oncology, Winship Cancer Institute, Emory University School of Medicine, C Clifton Road NE, Room C, Atlanta, GAUSA ([email protected]).

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